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My lab is interested in understanding the molecular basis of essential processes that regulate gene expression. We use biophysical, biochemical methods, and structural methods, including X-ray crystallography. Our insights into these fundamental mechanisms will contribute to a better understanding and ability to regulate gene expression processes involved in human diseases from cancer and heart disease to bacterial infections and will assist in drug development efforts.

Our studies focus on the following questions:

1. How is chromatin structure modulated for DNA-dependent processes?
2. How do transcription factors and pioneering factors activate gene expression?
3. How are genes coordinately regulated by quorum sensing in bacterial pathogens?