Research in the Tucker Lab focuses on the study and manipulation of protein interactions and pathways, including protein homeostasis and signaling pathways. In particular, we are interested in developing novel technologies that allow use of light for photocontrol of protein function. These engineered optogenetic tools allow regulation of molecular biochemistry and cellular behaviors in live cells with fast temporal and spatial precision. We are also developing ways to use these tools to visualize protein-protein interactions in a cellular context. In addition, we are also interested in developing approaches to characterize and rescue misfolded proteins, designing new genetic assays to characterize unstable human disease proteins, and developing sensors of ligand-binding events. The approaches we take in the lab are interdisciplinary, ranging from biochemistry and protein engineering, to yeast genetics and screening, to molecular biology, cell biology, and imaging.
- Chandra co-organizing workshop for ASCB, 'Probing the spatiotemporal limits: new imaging methods and molecular tools and their applications in cell biology'
- March 2017, Jess defends her thesis! Gopal and Jess's paper accepted in NAR.
- Nov 2016, Chandra co-organizer of Janelia farm workshop, 'Genetic control of neuronal activity IV'
- Sept 2016, Chrissy joins the lab!
-May 2016, Chandra speaks at EMBO Practical Course: Non-neuronal Optogenetics
- April 2016, Amir's paper "Optimized second generation CRY2/CIB dimerizers and photoactivatable Cre recombinase" in press at Nature Chemical Biology
- Dec 2015, optogenetics research highlighted in Nature magazine, 'Micromanagement with light'
- Tucker and Kennedy labs awarded Brain Initiative R21 grant to develop new neuronal tools! (Sept 2015)
|***We are often looking for motivated scientists at all levels- interested students and postdocs can contact us here***|
Mail Stop 8303, Box 6511, Aurora, CO 80045