Our research focuses on the study and manipulation of protein homeostasis and signaling pathways. In particular, we are interested in developing novel technologies for using light for photocontrol of protein activity. We are developing and engineering novel optogenetic tools that allow regulation of molecules in live cells with fast temporal and spatial precision. A second area of interest is in protein misfolding and stability. We are interested in developing approaches to characterize and rescue misfolded proteins, developing genetic assays in yeast to characterize unstable human disease proteins, and in studying protein misfolding and aggregation in the cytosol.
- Jan 2013: " Light-dependent, dark-promoted interaction between Arabidopsis cryptochrome1 and phytochrome B" chosen as one of the best papers published in JBC of the year!
- Nov 2012 -Manuscript "Rapid profiling of disease alleles using a tunable reporter of protein misfolding" highlighted in Nature Reviews Genetics!
- Amir's photo gets cover of Biology of the Cell:
|Lake Isabelle- Indian Peaks Wilderness|