Research in the Tucker Lab focuses on the study and manipulation of protein interactions and pathways, including protein homeostasis and signaling pathways. In particular, we are interested in developing novel technologies that allow use of light for photocontrol of protein function. These engineered optogenetic tools allow regulation of molecular biochemistry and cellular behaviors in live cells with fast temporal and spatial precision. We are also developing ways to use these tools to visualize protein-protein interactions in a cellular context. In addition, we are also interested in developing approaches to characterize and rescue misfolded proteins and unstable human disease proteins, and developing sensors of ligand-binding events. The approaches we take in the lab are interdisciplinary, ranging from biochemistry and protein engineering, to yeast genetics and screening, to molecular biology, cell biology, and imaging.


- Congrats to Carmen for being chosen for the 2019 Pew Latin American Fellows Program !!

-Jan 2019 - Light activated neurotoxin paper in press at Neuron!

Oct 2018 - Sarah joins the lab!

-Sept 2018 - Chandra co-organizer of Janelia 'Genetic control of neuronal activity V' workshop

Sept 2018 - Lab gets new Brain Initiative grant, collaboration with Kennedy and Ford labs.

Feb 2018 - Carmen joins the lab!

- Dec 2017: Chandra co-organizer of ASCB/EMBO workshop, 'Probing the spatiotemporal limits: new imaging methods and molecular tools and their applications in cell biology'


***We are often looking for motivated scientists at all levels- interested students and postdocs can contact us here***


Mail Stop 8303, Box 6511, Aurora, CO 80045